5 Essential Elements For stem cell
With the concept that a more rapid cell cycle is a key component of pluripotency, reprogramming efficiency is often enhanced. Approaches for increasing pluripotency via manipulation of cell cycle regulators include: overexpression of Cyclin D/Cdk4, phosphorylation of Sox2 at S39 and S253, overexpression of Cyclin A and Cyclin E, knockdown of Rb, an